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23rd Adaptation to technical and scientific progress (23rd ATP) to Regulation (EC) No 1272/2008 (CLP) has been published in the Official Journal of the European Union on 20 June 2025:

“Commission Delegated Regulation (EU) 2025/1222 of 2 April 2025 amending Regulation (EC) No 1272/2008 of the European Parliament and of the Council as regards the harmonised classification and labelling of certain substances”

It brings changes to the classification and labelling of some existing harmonized substances and adds new harmonized substances in Part 3 of Annex VI.

Quick overview in numbers:

- 22 new entries with an index number,

- 10 existing index number entries are replaced.

The 23rd ATP shall apply from 1 February 2027.


Here is a brief overview of the changes, covering some of the most commonly present substances.

New substances:

Substance name

Identifiers

Classification

Index No.

2-ethylhexanoic acid, monoester with propane-1,2-diol

CAS: 85114-00-7

EC: 285-503-5

H360D

607-776-00-5

N-1-naphthylaniline;N-phenylnaphthalen-1-amine

CAS: 90-30-2

EC: 201-983-0

H302
H373 (blood system, liver)
H317

612-300-00-4

Tetrairon tris(pyrophosphate); iron pyrophosphate

CAS: 10058-44-3

EC: 233-190-0

H319

026-005-00-8

Dinitrogen oxide

CAS: 10024-97-2

EC: 233-032-0

H360Df
H336
H372 (nervous system)
H420

007-031-00-9

 

Updates of existing entries:

Substance name

Identifiers

Classification

Index No.

2-Phenylpropene; α-Methylstyrene

CAS: 98-83-9

EC: 202-705-0

H226
H335
H317
H319
H351
H411

601-027-00-6

3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate;Isophorone diisocyanate

CAS: 4098-71-9

EC: 223-861-6

H330
H314
H317
H318
H334
H411

615-008-00-5

3-Iodo-2-propynyl butylcarbamate;3-Iodoprop-2-yn-1-yl butylcarbamate

CAS: 55406-53-6

EC: 259-627-5

H330
H302
H317
H318
H372 (larynx)
H400
H410

616-212-00-7

 

However, suppliers of substances and mixtures may classify, label and package in accordance with Regulation (EC) No 1272/2008, as amended by this Regulation, from the date of entry into force of this Regulation (10 July 2025).

If you need assistance in understanding the requirements of this ATP, we will be happy to assist you.

 

 

Disclaimer:
Information on this blog is prepared with utmost care, but it is not about (chemical) consulting, and the provider does not assume any responsibility or liability for the correctness, accuracy and up-to-dateness of published content. If you need advice for a specific case, you can write to us at bojan.dimic@bens-consulting.eu Information on this blog is prepared with utmost care, but it is not about (chemical) consulting, and the provider does not assume any responsibility or liability for the correctness, accuracy and up-to-dateness of published content. If you need advice for a specific case, you can write to us at bojan.dimic@bens-consulting.eu
SDS Other | January 6, 2026

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