
23rd Adaptation to technical and scientific progress (23rd ATP) to Regulation (EC) No 1272/2008 (CLP) has been published in the Official Journal of the European Union on 20 June 2025:
“Commission Delegated Regulation (EU) 2025/1222 of 2 April 2025 amending Regulation (EC) No 1272/2008 of the European Parliament and of the Council as regards the harmonised classification and labelling of certain substances”
It brings changes to the classification and labelling of some existing harmonized substances and adds new harmonized substances in Part 3 of Annex VI.
Quick overview in numbers:
- 22 new entries with an index number,
- 10 existing index number entries are replaced.
The 23rd ATP shall apply from 1 February 2027.
Here is a brief overview of the changes, covering some of the most commonly present substances.
New substances:
|
Substance name |
Identifiers |
Classification |
Index No. |
|
2-ethylhexanoic acid, monoester with propane-1,2-diol |
CAS: 85114-00-7 EC: 285-503-5 |
H360D |
607-776-00-5 |
|
N-1-naphthylaniline;N-phenylnaphthalen-1-amine |
CAS: 90-30-2 EC: 201-983-0 |
H302 |
612-300-00-4 |
|
Tetrairon tris(pyrophosphate); iron pyrophosphate |
CAS: 10058-44-3 EC: 233-190-0 |
H319 |
026-005-00-8 |
|
Dinitrogen oxide |
CAS: 10024-97-2 EC: 233-032-0 |
H360Df |
007-031-00-9 |
Updates of existing entries:
|
Substance name |
Identifiers |
Classification |
Index No. |
|
2-Phenylpropene; α-Methylstyrene |
CAS: 98-83-9 EC: 202-705-0 |
H226 |
601-027-00-6 |
|
3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate;Isophorone diisocyanate |
CAS: 4098-71-9 EC: 223-861-6 |
H330 |
615-008-00-5 |
|
3-Iodo-2-propynyl butylcarbamate;3-Iodoprop-2-yn-1-yl butylcarbamate |
CAS: 55406-53-6 EC: 259-627-5 |
H330 |
616-212-00-7 |
However, suppliers of substances and mixtures may classify, label and package in accordance with Regulation (EC) No 1272/2008, as amended by this Regulation, from the date of entry into force of this Regulation (10 July 2025).
If you need assistance in understanding the requirements of this ATP, we will be happy to assist you.





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